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      Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

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          Abstract

          Up-regulation of gamma-aminobutyric acidA (GABAA) receptors and decreased GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic transmission, which could be caused by primary disturbance of GABA synapses or by decreased production of the transmitter. Decreased production could be due to a shutdown in GABA production or to loss of GABA neurons caused by cell death or their failure to migrate to the cortex during brain development.

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          Author and article information

          Journal
          Arch Gen Psychiatry
          Archives of general psychiatry
          American Medical Association (AMA)
          0003-990X
          0003-990X
          Apr 1995
          : 52
          : 4
          Affiliations
          [1 ] Department of Anatomy and Neurobiology, University of California-Irvine, USA.
          Article
          10.1001/archpsyc.1995.03950160008002
          7702443
          9847ed2f-dd68-46cc-931d-550531528e3a
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