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      Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum

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          Abstract

          Five pairs of optically pure meroterpenoid enantiomers ( 1a/1b–5a/5b) and two known compounds ( 6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b–5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new meroterpenoids with different polycyclic systems. Two enantiomeric pairs ( 2a/2b and 3a/3b), 6, and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) in vitro.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 963-969
          Affiliations
          1 School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China
          2 National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
          Author notes
          *Corresponding author: LEI Chun, Tel/Fax: 86-21-51980138, E-mails: chunlei@ 123456fudan.edu.cn ; HOU Ai-Jun, ajhou@ 123456shmu.edu.cn

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30119-0
          10.1016/S1875-5364(19)30119-0
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81222045
          Funded by: Fudan-SIMM Joint Research Fund
          Award ID: FU-SIMM20181011
          This work was supported by the National Natural Science Foundation of China (No. 81222045) and the Fudan-SIMM Joint Research Fund (No. FU-SIMM20181011).
          Categories
          Research article

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