Lipomas are rare and benign colonic soft tissue lesions derived from mature adipocytes. Their poor clinical expression usually leads to a coincidental discovery during procedures like colonoscopy, imagery, surgery or autopsy. Due to their small size, a simple observation would usually be recommended. However, colonic lipomas (CLs) with clinical symptoms or signs including abdominal pain, nausea, vomiting, diarrhea, anaemia or even intussusception would need invasive treatment. It is recommended to perform surgery to treat CLs that are >2 cm. Endoscopic procedures could be an interesting alternative for the future but would still require further investigation. We report the case of a 30-year-old patient with transverse CLs leading to obstruction of the descending colon by intussusception and continue by presenting a review of the current literature.