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Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
Justin B Miller
1 ,
Elizabeth Ward
1 ,
Lyndsay A Staley
1 ,
Jeffrey Stevens
2 ,
Craig C Teerlink
2 ,
Justina P Tavana
1 ,
Matthew Cloward
1 ,
Madeline Page
1 ,
Louisa Dayton
1 ,
Lisa A Cannon-Albright
2 ,
John S K Kauwe
4
September 2020
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Abstract
Longevity as a phenotype entails living longer than average and typically includes living without chronic age-related diseases. Recently, several common genetic components to longevity have been identified. This study aims to identify additional genetic variants associated with longevity using unique and powerful analyses of pedigrees with a statistical excess of healthy elderly individuals identified in the Utah Population Database (UPDB).