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      Functional and Non-Functional Nerve-Smooth Muscle Transmission in the Renal Arteries of the Newborn and Adult Rabbit and Guinea-Pig

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          Abstract

          Isolated renal arteries from newborn and adult guinea-pigs failed to respond to electrical stimulation of the intramural nerves, using parameters identical to those which elicit large neurogenic contractions in renal arteries from newborn and adult rabbits. The threshold stimulation frequency was lower and responses were greater in adult compared with neonatal rabbits. Comparisons of noradrenaline EC<sub>50</sub> values showed that guinea-pig renal arteries are significantly less sensitive to noradrenaline than rabbit vessels. Quantitative fluorescence histochemistry of the perivascular adrenergic nerves in renal arteries revealed that the density of innervation gradually declines in the guinea-pig but substantially increases in the rabbit during postnatal development. The lack of neurogenic response of the guinea-pig renal artery, despite the existence of a varicose, adrenergic nerve plexus, is discussed.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1982
          1982
          19 September 2008
          : 19
          : 5
          : 237-246
          Affiliations
          Department of Anatomy and Embryology and Centre for Neuroscience, University College London, England
          Article
          158390 Blood Vessels 1982;19:237–246
          10.1159/000158390
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Research Paper

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