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      Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

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          Abstract

          It is increasingly recognized that there is a connection between diet, intestinal microbiota, intestinal barrier function and the low-grade inflammation that characterizes the progression from obesity to metabolic disturbances, making dietary strategies to modulate the intestinal environment relevant. In this context, the ability of some Gram-positive anaerobic bacteria to produce the short-chain fatty acid butyrate is interesting. A lower abundance of butyrate-producing bacteria has been associated with metabolic risk in humans, and recent studies suggest that butyrate might have an anti-inflammatory potential that can alleviate obesity-related metabolic complications, possibly due to its ability to enhance the intestinal barrier function. Here, we review and discuss the potential of butyrate as an anti-inflammatory mediator in metabolic diseases, and the potential for dietary interventions increasing the intestinal availability of butyrate.

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          Author and article information

          Journal
          Obes Rev
          Obesity reviews : an official journal of the International Association for the Study of Obesity
          1467-789X
          1467-7881
          Dec 2013
          : 14
          : 12
          Affiliations
          [1 ] Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
          Article
          10.1111/obr.12068
          23947604
          © 2013 The Authors. obesity reviews © 2013 International Association for the Study of Obesity.

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