Oncogene Organisation and Expression: Prediction in Breast Cancer

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Abstract

The aim of the present study was to identify genes whose expression and/or organisation are altered in the diseased breast, as compared to the normal breast. Alteration of one or more genes examined has been found to occur in over 60% of breast tumour samples. Changes to three cellular proto-oncogenes are frequent, and amplification of two of these genes correlates with poor short-term prognosis. Deletion of RB-1 a tumour suppressor gene, has been detected and although these deletions do not correlate with poor prognosis, they occur more commonly in advanced tumours. A loss of sequences encoding the progesterone receptors has also been found to be frequent.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5105-2

ISBN: 978-3-318-01977-3

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 02 December 2008

Volume: 32

Issue: Suppl 1

Pages: 250-253

Affiliations

^aICI/University Joint Laboratory and ^bDepartment of Pathology, University of Leicester, UK

Article

Publisher ID: 181357 Other ID: Horm Res 1989;32:250–253

DOI: 10.1159/000181357

PubMed ID: 2613210

SO-VID: 98832568-ff9b-4584-ae67-19d4a6a8c9a8

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Oncogene Organisation and Expression: Prediction in Breast Cancer

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Karger: Endocrinology

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