There are three key points in logistics distribution: the distribution vehicle, the amount of goods, and the distribution path. Comprehensive calculation and optimization of these three parameters can plan a reasonable and efficient distribution scheme, especially the distribution path. This study aims to study the method of optimizing the logistics distribution path and strives to find the optimal distribution scheme and the shortest path, which can reduce the distribution error rate, distribution time, and labor costs, thus realizing intelligent management. In this study, intelligent management methods such as radio-frequency identification technology and ant colony algorithm are proposed to optimize the logistics distribution path and realize the safe and efficient logistics distribution. The experimental results of this study show that for the current logistics distribution, the RFID system has a positioning rate of close to 100% when the number of fixed points reaches about 300, and almost all accurate positioning is achieved. The ant colony algorithm can also accurately find the shortest distance after selecting appropriate parameters, which is about 200 meters away from the actual shortest distance.