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      Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.

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          Abstract

          The guidance of developing axons in the nervous system is mediated partly by diffusible chemoattractants secreted by axonal target cells. Netrins are chemoattractants for commissural axons in the vertebrate spinal cord, but the mechanisms through which they produce their effects are unknown. We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Moreover, an antibody to DCC selectively blocks the netrin-1-dependent outgrowth of commissural axons in vitro. These results indicate that DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. elegans and Drosophila.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Oct 18 1996
          : 87
          : 2
          Affiliations
          [1 ] Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143-0452, USA.
          Article
          S0092-8674(00)81336-7
          10.1016/s0092-8674(00)81336-7
          8861902
          9897be9e-3a04-4c66-9aa9-5c8c3f5ebdc4
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