We develop a general framework for the open dynamics of an ensemble of quantum particles subject to spacetime fluctuations about the flat background. An arbitrary number of interacting bosonic and fermionic particles are considered. A systematic approach to the generation of gravitational waves in the quantum domain is presented that recovers known classical limits in terms of the quadrupole radiation formula and back-reaction dissipation. Classical gravitational emission and absorption relations are quantized into their quantum field theoretical counterparts in terms of the corresponding operators and quantum ensemble averages. Certain arising consistency issues related to factor ordering have been addressed and resolved. Using the theoretical formulation established here with numerical simulations in the quantum regime, we demonstrate new predictions including decoherence through the spontaneous emission of gravitons and collectively amplified "superradiance" of gravitational waves by a highly coherent state of identical particles.