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      Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals.

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          Abstract

          Micro ribonucleic acids (miRNAs) are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone-related physiological pathways. Estrogens, thyroid hormones, and gonadotropins are all known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control mechanisms. Research on cancer biology has also recently considered miRNA as therapeutic targets, because the deregulation of specific miRNAs in various tissues has been correlated with tumorigenesis and other carcinogenic responses. Because many pharmaceuticals are considered to be endocrine-disrupting chemicals (EDCs), their effects on miRNAs may be important to our understanding of basic physiological control and phenotypic outcomes of wildlife exposed to EDCs. Presented is a brief overview of the synthesis, control, and action of miRNAs, focusing on endocrine systems. The antidepressant fluoxetine will be used as an example for miRNA studies in aquatic species, one of the few examples in ecotoxicology. Given the mounting evidence that miRNAs are regulated by hormones, a clear need exists to investigate the potential for environmental EDCs to deregulate miRNA expression and action.

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          Author and article information

          Journal
          Environ. Toxicol. Chem.
          Environmental toxicology and chemistry / SETAC
          1552-8618
          0730-7268
          Apr 2016
          : 35
          : 4
          Affiliations
          [1 ] Department of Biology, University of Ottawa, Ontario, Canada.
          [2 ] Department of Biology, University of Waterloo, Ontario, Canada.
          Article
          10.1002/etc.3063
          25982118
          98ada1b5-9276-487b-9bb3-f4db03190cc8
          © 2015 SETAC.
          History

          Ecotoxicology,Endocrine-disrupting chemicals,Fluoxetine,Pharmaceuticals,microRNA

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