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      Polymer-Based Electrospun Nanofibers for Biomedical Applications

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          Abstract

          Electrospinning has been considered a promising and novel procedure to fabricate polymer nanofibers due to its simplicity, cost effectiveness, and high production rate, making this technique highly relevant for both industry and academia. It is used to fabricate non-woven fibers with unique characteristics such as high permeability, stability, porosity, surface area to volume ratio, ease of functionalization, and excellent mechanical performance. Nanofibers can be synthesized and tailored to suit a wide range of applications including energy, biotechnology, healthcare, and environmental engineering. A comprehensive outlook on the recent developments, and the influence of electrospinning on biomedical uses such as wound dressing, drug release, and tissue engineering, has been presented. Concerns regarding the procedural restrictions and research contests are addressed, in addition to providing insights about the future of this fabrication technique in the biomedical field.

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          Most cited references123

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          Electrospinning: applications in drug delivery and tissue engineering.

          Despite its long history and some preliminary work in tissue engineering nearly 30 years ago, electrospinning has not gained widespread interest as a potential polymer processing technique for applications in tissue engineering and drug delivery until the last 5-10 years. This renewed interest can be attributed to electrospinning's relative ease of use, adaptability, and the ability to fabricate fibers with diameters on the nanometer size scale. Furthermore, the electrospinning process affords the opportunity to engineer scaffolds with micro to nanoscale topography and high porosity similar to the natural extracellular matrix (ECM). The inherently high surface to volume ratio of electrospun scaffolds can enhance cell attachment, drug loading, and mass transfer properties. Various materials can be electrospun including: biodegradable, non-degradable, and natural materials. Electrospun fibers can be oriented or arranged randomly, giving control over both the bulk mechanical properties and the biological response to the scaffold. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, and RNA can be incorporated into electrospun scaffolds. Suspensions containing living cells have even been electrospun successfully. The applications of electrospinning in tissue engineering and drug delivery are nearly limitless. This review summarizes the most recent and state of the art work in electrospinning and its uses in tissue engineering and drug delivery.
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            Electrospinning process and applications of electrospun fibers

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              Electrospinning of Polymeric and Ceramic Nanofibers as Uniaxially Aligned Arrays

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                Author and article information

                Journal
                Nanomaterials (Basel)
                Nanomaterials (Basel)
                nanomaterials
                Nanomaterials
                MDPI
                2079-4991
                20 April 2018
                April 2018
                : 8
                : 4
                : 259
                Affiliations
                [1 ]Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; amenizi@ 123456ksu.edu.sa
                [2 ]Materials Science and Technology Program, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar; mmsalah@ 123456qu.edu.qa
                Author notes
                [* ]Correspondence: aelzatahry@ 123456qu.edu.qa ; Tel.: +974-4403-6808
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-7291-5723
                Article
                nanomaterials-08-00259
                10.3390/nano8040259
                5923589
                29677145
                98b00049-ccc1-4bd9-8330-a5b236e1feff
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 17 February 2018
                : 09 April 2018
                Categories
                Review

                electrospinning,nanofibers,medical prostheses,wound dressing,drug release,tissue engineering,blood vessels,bone

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