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      Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.

      Science (New York, N.Y.)

      Two-Hybrid System Techniques, pharmacology, metabolism, chemistry, Sulfonamides, Signal Transduction, growth & development, Seeds, Recombinant Fusion Proteins, Protein Binding, antagonists & inhibitors, Phosphoprotein Phosphatases, Naphthalenes, Mutation, genetics, Membrane Transport Proteins, Ligands, drug effects, Germination, Genes, Plant, Arabidopsis Proteins, enzymology, Arabidopsis, agonists, Abscisic Acid

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          Abstract

          Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.

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          Journal
          10.1126/science.1173041
          2827199
          19407142

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