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      A Genomic and Functional Inventory of Deubiquitinating Enzymes

      , , , , , ,
      Cell
      Elsevier BV

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          Abstract

          Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important but are less well understood. Here, we present an inventory of the deubiquitinating enzymes encoded in the human genome. In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          December 2005
          December 2005
          : 123
          : 5
          : 773-786
          Article
          10.1016/j.cell.2005.11.007
          16325574
          98cdee31-ae7e-4540-89c6-2daae50c238e
          © 2005

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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