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      Role of Alpha 1- and Alpha 2-Adrenergic Receptors in the Growth Hormone and Prolactin Response to Insulin-Induced Hypoglycemia in Man

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          Abstract

          The effects of intravenous infusion of the nonselective alpha-adrenergic antagonist phentolamine or of the selective alpha2-adrenergic antagonist yohimbine on growth hormone (GH), prolactin (PRL) and cortisol secretion during insulin-induced hypoglycemia were studied in 11 healthy young men. The GH response was blunted following each antagonist used, PRL secretion was higher after yohimbine and diminished after phentolamine when compared to controls. The plasma cortisol response was not influenced by either compound. In another series of experiments no effect of an oral administration of prazosin, a selective alphai-adrenergic antagonist, on the secretion of GH, PRL and cortisol was found in any of 7 subjects. Prazosin inhibited blood pressure increase during hypoglycemia and induced slight drowsiness and fatigue in the subjects. It is concluded that in man alpha-adrenergic stimulation of GH secretion during hypoglycemia is transmitted via alpha2-receptors, PRL secretion is mediated via alphai-receptors, whereas inhibition of PRL release is mediated via alpha2-receptors. In this experiment no effect of alpha<sub>1</sub>- or alpha<sub>2</sub>-blockade on cortisol response to hypoglycemia was seen.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1984
          1984
          28 March 2008
          : 39
          : 3
          : 275-280
          Affiliations
          Research Institute for Human Bioclimatology and Institute of Experimental Endocrinology, Bratislava, Czechoslovakia
          Article
          123991 Neuroendocrinology 1984;39:275–280
          10.1159/000123991
          6095132
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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