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      Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability.

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          Abstract

          The aim of this work was to compare and contrast the mechanical properties and physical stabilities of oral films prepared with either thermal ink-jet printing (TIJP) or solvent casting (SC). Clonidine hydrochloride was selected as a model drug because of its low therapeutic dose and films were prepared using cellulose polymers. Mechanical testing showed that the printed films had Young's moduli and tensile strength values similar to the free film, while casted films were significantly more brittle. The drug also appeared to crystallize out of casted films during stress testing whereas printed films remained unchanged. The dissolution behavior of printed and cast films were similar, because of the rapid disintegration of the polymer. The conclusion is that printing resulted in a better film than casting because the drug resided on the film, rather than in the film where it could exert a plasticizing effect.

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          Author and article information

          Journal
          Int J Pharm
          International journal of pharmaceutics
          Elsevier BV
          1873-3476
          0378-5173
          Oct 30 2015
          : 494
          : 2
          Affiliations
          [1 ] UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
          [2 ] UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address: s.gaisford@ucl.ac.uk.
          Article
          S0378-5173(14)00929-6
          10.1016/j.ijpharm.2014.12.032
          25526674
          98ddbc13-9bff-46b8-806b-ddf26c4b0032
          History

          Thermal ink-jet printing,Critical humidity,Dynamic mechanical analysis,Oral films,Clonidine

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