Sustained neuroprotection from a single intravitreal injection of PGJ₂ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy.

Miller, Neil R.; Johnson, Mary A.; Nolan, Theresa; Guo, Yan R.; Bernstein, Alexander M; Bernstein, Steven L.

doi:10.1167/iovs.14-14063

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Sustained neuroprotection from a single intravitreal injection of PGJ₂ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy.

Author(s): Neil R Miller ¹ , Mary A Johnson ² , Theresa Nolan ³ , Yan Guo ² , Alexander M Bernstein ² , Steven L Bernstein ²

Publication date (Electronic): Oct 08 2014

Journal: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

Keywords: 15d-prostaglandin J2, PGJ2, anterior ischemic optic neuropathy, intravitreal injection, ischemia, neuroprotection, white matter

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Abstract

Prostaglandin J₂ (PGJ₂) is neuroprotective in a murine model of nonarteritic anterior ischemic optic neuropathy (NAION). After assessing for potential toxicity, we evaluated the efficacy of a single intravitreal (IVT) injection of PGJ₂ in a nonhuman primate model of NAION (pNAION).

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Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Oct 08 2014

Volume: 55

Issue: 11

Affiliations

[1 ] Wilmer Eye Institute, the Johns Hopkins Medical Institutions, Baltimore, Maryland, United States Department of Ophthalmology and Visual Science, University of Maryland Medical Center, Baltimore, Maryland, United States.

[2 ] Department of Ophthalmology and Visual Science, University of Maryland Medical Center, Baltimore, Maryland, United States.

[3 ] Department of Veterinary Resources, University of Maryland Medical Center, Baltimore, Maryland, United States.

Article

Publisher Item ID: iovs.14-14063

DOI: 10.1167/iovs.14-14063

PMC ID: 4222271

PubMed ID: 25298416

SO-VID: 98e03863-6531-4965-b6f6-b87cb0585bae

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Keywords: 15d-prostaglandin J2,PGJ2,anterior ischemic optic neuropathy,intravitreal injection,ischemia,neuroprotection,white matter

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Keywords: 15d-prostaglandin J2, PGJ2, anterior ischemic optic neuropathy, intravitreal injection, ischemia, neuroprotection, white matter

Sustained neuroprotection from a single intravitreal injection of PGJ₂ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy.

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