Ethylene Glycol Poisoning in the Czech Republic (2000–2002)

Abstract

Background: The objective of the study was to evaluate the severity of kidney damage retrospectively and to analyze prognostic factors following ethylene glycol (EG) poisonings. Methods: Data concerning the clinical course of patients with EG poisoning between 2000 and 2002 were analyzed. The χ² test, Student’s t test, Fisher’s test and the calculation of linear correlation coefficients were used for statistical analysis. Results: Thirty-three discharge records were obtained. Three patients died, and 11 patients developed acute renal failure (mean maximum serum creatinine level 618 µmol/l). Upon discharge, serum creatinine levels were still elevated in 10 patients. In all but 1 patient, renal function completely normalized within 20 months after intoxication. Conclusion: Adult men are the most endangered segment of the population. The most important prognostic factors are the ingested dose and early antidotal treatment. EG toxic kidney damage is reversible.

Journal

Journal ID (publisher-id): BPU

Journal ID (nlm-ta): Blood Purif

Journal ID (doi): 10.1159/issn.0253-5068

Title: Blood Purification

Publisher: S. Karger AG

ISSN (Print): 0253-5068

ISSN (Electronic): 1421-9735

Publication date Subscription-year: 2006

Publication date (Print): February 2006

Publication date (Electronic): 15 February 2006

Volume: 24

Issue: 2

Pages: 180-184

Affiliations

^aToxicological Information Centre, Department of Occupational Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital, ^bJ. Heyrovský Institute of Physical Chemistry, and ^c1st Medical Department, Clinical Department of Hematology and Nephrology, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic

Article

Publisher ID: 90516 Other ID: Blood Purif 2006;24:180–184

DOI: 10.1159/000090516

PubMed ID: 16373995

Copyright statement: © 2006 S. Karger AG, Basel

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Page count

Tables: 3, References: 18, Pages: 5

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Categories

Subject: Original Paper