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      Mobilization of Renal Carnosine and Histidine to Histamine during Compound-48/80-Induced Shock

      a , b , a

      Nephron

      S. Karger AG

      Carnosine, Histidine, Histamine, Compound 48/80

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          Abstract

          Recently the presence of carnosine in the kidney has been established, and several potential roles for histamine have been proposed in renal metabolism. Histamine is known to occur in relatively high concentrations in renal tissue of several species and has been implicated in the autoregulation of renal blood flow and glomerular filtration. This study was designed to evaluate the effect ofshock produced by compound 48/80 on the mobilization of renal carnosine to histamine and the effects of various blocking agents such as lodoxamide, diphenhydramine and cimetidine on this mobilization. Our results showed that compound-48/80-induced shock causes significant mobilization of renal carnosine and histidine to histamine and that this response can be blocked by administration of lodoxamide and diphenhydramine, but not cimetidine.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1991
          1991
          11 December 2008
          : 59
          : 2
          : 299-303
          Affiliations
          aDepartment of Surgery, UMDNJ-Robert Wood Johnson Medical School, and bDepartment of Nutrition, Rutgers University, New Brunswick, N.J., USA
          Article
          186568 Nephron 1991;59:299–303
          10.1159/000186568
          1956492
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Carnosine, Histamine, Histidine, Compound 48/80

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