Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Functional Anatomy of the Interventricular Septum

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Structure-function studies were performed upon the canine in situ interventricular septum. In response to both neural and chemical stimulation, the left septal apex generated greater percent change in contractile force, and contracted earlier than did the basal portion. Under positive inotropic stimulation the left septum contracted earlier and more forcefully than the right. Coarctation of the pulmonary artery elicited moderate augmentation in right septal contraction with no change in the left, whereas partial occlusion of the aorta resulted in increased contractile force in both septa with predominance on the left. Stimulation of the peripheral end of the cervical vagosympathetic trunk induced comparable suppression in contractile force of all surfaces of the septum as well as in both right and left epicardial muscle segments. Based upon careful anatomical dissection of fresh specimens, the interventricular septum was found to be comprised of thin right and relatively thick left muscle masses. The septum may be divided into three different structural zones. The cranial portion is small and consists of a very thin membranous region. The muscular septum is divisible into cranial and caudal portions, each demonstrating characteristic contractile behaviors which are exaggerated under neurally and chemically augmented states and which play an important role in regulation of cardiac output.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 2
          : 65-79
          Affiliations
          Department of Physiology, Loyola University, Stritch School of Medicine, Maywood, Ill.
          Article
          169619 Cardiology 1973;58:65–79
          10.1159/000169619
          4750797
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 15
          Categories
          Paper

          Comments

          Comment on this article