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      L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan 35S Incorporation in Rabbit-Induced Atherogenesis

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          The effects of L-ascorbic acid on <sup>35</sup>S-incorporation into thoracic aorta glycosaminoglycans and upon aorta cholesterol levels were determined in hypercholesterolemic rabbits. No significant difference was observed in serum free or esterified cholesterol levels between animals receiving L-ascorbic acid supplementation or saline while maintained on a cholesterol diet (0.5%). A 15-fold higher serum cholesterol was observed in animals on the cholesterol diet to those animals which received a normal rabbit (Purina) diet. L-Ascorbic acid increased sulfated glycosaminoglycans concentrations in hypercholesterolemic rabbits which paralleled lower tissue free and esterified cholesterol levels. The <sup>35</sup>S-specific activity of glycosaminoglycans in hypercholesterolemic animals receiving saline was much greater than in those animals receiving L-ascorbic acid. This suggests that L -ascorbic acid plays a role in the maintenance of adequate levels of aortic sulfated glycosaminoglycans. This then is a suggested biochemical mechanism of L-ascorbic acids interaction in the atherogenic process.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 16
          : 4
          : 177-185
          Department of Animal Sciences, Cook College, Rutgers – The State University, New Brunswick, N.J.
          158205 Blood Vessels 1979;16:177–185
          © 1979 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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