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      Can the presence of KRAS mutations guide the type of liver resection during simultaneous resection of colorectal liver metastasis?

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          Abstract

          Backgrounds/Aims

          It is generally accepted that non-anatomical resection (NAR) in colorectal liver metastasis (CRLM) has comparable safety and efficacy compared to anatomical resection (AR); however, there are reports that AR may have better outcomes in KRAS mutated CRLM. This study aimed to determine the effects of KRAS mutations and surgical techniques on survival outcomes in CRLM patients.

          Methods

          Two hundred fifty patients who underwent hepatic resection of CRLM with known KRAS mutational status between 2007 and 2018 were analyzed. A total of 94 KRAS mutated CRLM and 156 KRAS wild-type CRLM were subdivided by surgical approach and compared for short- and long-term outcomes.

          Results

          In both KRAS wild-type and mutated type, there was no difference in estimated blood loss, postoperative complications, and 30-day mortality. There was no difference in disease-free survival (DFS) between AR and NAR in both groups ( p = 0.326, p = 0.954, respectively). Finally, there was no difference in intrahepatic DFS between AR and NAR groups in both the KRAS groups ( p = 0.165, p = 0.516, respectively).

          Conclusions

          The presence of KRAS mutation may not be a significant factor when deciding the approach in simultaneous resection of CRLM.

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          Most cited references25

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          Actual 10-year survival after resection of colorectal liver metastases defines cure.

          Resection of colorectal liver metastases (CLM) in selected patients has evolved as the standard of care during the last 20 years. In the absence of prospective randomized clinical trials, a survival benefit has been deduced relative to historical controls based on actuarial data. There is now sufficient follow-up on a significant number of patients to address the curative intent of resecting CLM. Retrospective review of a prospectively maintained database was performed on patients who underwent resection of CLM from 1985 to 1994. Postoperative deaths were excluded. Disease-specific survival (DSS) was calculated from the time of hepatectomy using the Kaplan-Meier method. There were 612 consecutive patients identified with 10-year follow-up. Median DSS was 44 months. There were 102 actual 10-year survivors. Ninety-nine (97%) of the 102 were disease free at last follow-up. Only one patient experienced a disease-specific death after 10 years of survival. In contrast, 34% of the 5-year survivors suffered a cancer-related death. Previously identified poor prognostic factors found among the 102 actual 10-year survivors included 7% synchronous disease, 36% disease-free interval less than 12 months, 25% bilobar metastases, 50% node-positive primary, 39% more than one metastasis, and 35% tumor size more than 5 cm. Patients who survive 10 years appear to be cured of their disease, whereas approximately one third of actual 5-year survivors succumb to a cancer-related death. In well-selected patients, there is at least a one in six chance of cure after hepatectomy for CLM. The presence of poor prognostic factors does not preclude the possibility of long-term survival and cure.
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            Colorectal cancer liver metastases – a population-based study on incidence, management and survival

            Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidence of liver metastases. The aim of the study was to describe the liver metastatic patterns and survival as a function of the characteristics of the primary tumour and different combinations of metastatic disease. Methods A retrospective population-based study was performed on a cohort of patients diagnosed with CRC in the region of Stockholm, Sweden during 2008. Patients were identified through the Swedish National Quality Registry for Colorectal Cancer Treatment (SCRCR) and additional information on intra- and extra-hepatic metastatic pattern and treatment were retrieved from electronic patient records. Patients were followed for 5 years or until death. Factors influencing overall survival (OS) were investigated by means of Cox regression. OS was compared using Kaplan-Meier estimations and the log-rank test. Results Liver metastases were diagnosed in 272/1026 (26.5%) patients within five years of diagnosis of the primary. Liver and lung metastases were more often diagnosed in left-sided colon cancer compared to right-sided cancer (28.4% versus 22.1%, p = 0.029 and 19.7% versus 13.2%, p = 0.010, respectively) but the extent of liver metastases were more extensive for right-sided cancer as compared to left-sided (p = 0.001). Liver metastatic left-sided cancer, including rectal cancer, was associated with a 44% decreased mortality risk compared to right-sided cancer (HR = 0.56, 95% CI: 0.39–0.79) with a 5-year OS of 16.6% versus 4.3% (p < 0.001). In liver metastatic CRC, the presence of lung metastases did not significantly influence OS as assessed by multivariate analysis (HR = 1.11, 95% CI: 0.80–1.53). Conclusion The worse survival in liver metastatic right-sided colon cancer could possibly be explained by the higher number of metastases, as well as more extensive segmental involvement compared with left-sided colon and rectal cancer, even though the latter had a higher incidence of liver metastases. Detailed population-based data on the metastatic pattern of CRC and survival could assist in more structured and individualized guidelines for follow-up of patients with CRC. Electronic supplementary material The online version of this article (10.1186/s12885-017-3925-x) contains supplementary material, which is available to authorized users.
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              RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases.

              To determine the impact of RAS mutation status on survival and patterns of recurrence in patients undergoing curative resection of colorectal liver metastases (CLM) after preoperative modern chemotherapy.
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                Author and article information

                Journal
                Ann Hepatobiliary Pancreat Surg
                Ann Hepatobiliary Pancreat Surg
                Annals of Hepato-Biliary-Pancreatic Surgery
                The Korean Association of Hepato-Biliary-Pancreatic Surgery
                2508-5778
                2508-5859
                31 May 2022
                18 April 2022
                18 April 2022
                : 26
                : 2
                : 125-132
                Affiliations
                [1 ]Department of Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
                [2 ]Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
                Author notes
                Corresponding author: Gi Hong Choi Department of Surgery, Yonsei University College of Medicine, Ludlow Faculty Research Building, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel: +82-2-2228-2099, Fax: +82-2-313-8289, E-mail: CHOIGH@ 123456yuhs.ac ORCID: https://orcid.org/0000-0002-1593-3773
                Author information
                https://orcid.org/0000-0002-9844-4747
                https://orcid.org/0000-0003-2787-7876
                https://orcid.org/0000-0002-6467-6494
                https://orcid.org/0000-0002-1593-3773
                Article
                ahbps-26-2-125
                10.14701/ahbps.21-127
                9136426
                35431183
                993fdda5-36ae-410d-88f1-2981945144c6
                Copyright © 2022 by The Korean Association of Hepato-Biliary-Pancreatic Surgery

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 14 September 2021
                : 3 January 2022
                : 14 January 2022
                Categories
                Original Article

                kras,neoplasm metastasis,hepatectomy,liver
                kras, neoplasm metastasis, hepatectomy, liver

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