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Regulation of cell death: the calcium-apoptosis link.

Nature reviews. Molecular cell biology

Signal Transduction, Necrosis, physiology, Mitochondria, Humans, Homeostasis, Enzyme Activation, Calcium Signaling, Calcium, Apoptosis, Animals

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      Abstract

      To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.

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      Journal
      10.1038/nrm1150
      12838338

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