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      Effects of Chronic Intracerebroventricular GABAergic Treatment on Basal and Chronic or Acute Stress-Induced Adrenocortical Activities in the Thalamic Pigeon

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          Abstract

          Muscimol was chronically administrated to the third ventricle of thalamic pigeons by means of osmotic minipumps at the rate of 0.25 µg·h<sup>–1</sup> for 28 days. No abnormal behavioural sign was noted. The animals were subjected daily to chronic intermittent stress for the same 28-day period. Basal and stress-induced adrenocortical activities were evaluated by recording serial plasma corticosterone levels at the end of the experimental session. Untreated controls exhibited both components of the adaptation of the adrenocortical response to chronic stress: (1) attenuation, i.e., a decrease in magnitude and disappearance of the late rebounding phenomenon, and (2) anticipation, i.e., the occurrence of a conditioned component before stress itself. The adaptation to chronic stress was partly impaired by GABAergic treatment. The anticipatory conditioned peak subsisted but the magnitude of the post-stress peak was found not to be reduced whereas rebounding events were suppressed after chronic as well as acute stress. The basal resting levels of corticosterone were significantly lowered in muscimol-treated animals. A lesion placement in the anterior dorsomedial thalamus (ADMT) resulted in the same profile of stress-induced plasma corticosterone levels as seen after muscimol administration. Adaptation did not develop in ADMT animals and GABAergic stimulation, either acute or chronic, had no effect on their response to stress.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1986
          1986
          01 April 2008
          : 44
          : 4
          : 408-414
          Affiliations
          Laboratory of General Physiology, University Montpellier II, Montpellier, France
          Article
          124679 Neuroendocrinology 1986;44:408–414
          10.1159/000124679
          3029613
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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