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      Hollow copper sulfide nanoparticle-mediated transdermal drug delivery.

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          Abstract

          A photothermal ablation-enhanced transdermal drug delivery methodology is developed based on hollow copper sulfide nanoparticles (HCuSNPs) with intense photothermal coupling effects. Application of nanosecond-pulsed near-infrared laser allows rapid heating of the nanoparticles and instantaneous heat conduction. This provides very short periods of time but extremely high temperatures in local regions, with focused thermal ablation of the stratum corneum. The depth of skin perforations can be controlled by adjusting the laser power. Skin disruption by HCuSNP-mediated photothermal ablation significantly increases the permeability of human growth hormone. This technique offers compelling opportunities for macromolecular drug and vaccine delivery.

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          Author and article information

          Journal
          Small
          Small (Weinheim an der Bergstrasse, Germany)
          1613-6829
          1613-6810
          Oct 22 2012
          : 8
          : 20
          Affiliations
          [1 ] Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA.
          Article
          NIHMS414144
          10.1002/smll.201200783
          3485307
          22829400
          9961ccfc-1013-4bbb-85d8-b9075e160c57
          Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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