Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China.

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Abstract

We characterized two novel highly pathogenic H5N6 influenza viruses isolated from Chinese poultry in 2013. Genomic analysis showed that both isolates were reassortants, and derived their genes from H5 and H6 subtype viruses found in poultry in China. The virulence of the two isolates was examined in chickens and mice, and both isolates were found to be highly pathogenic in chickens and only moderately virulent for mice. Our results show that continued circulation of these viruses could endanger both avian species and humans.

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Author and article information

Journal

Journal ID (iso-abbrev): Infect. Genet. Evol.

Title: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

ISSN (Electronic): 1567-7257

ISSN (Print): 1567-1348

Publication date (Electronic): Apr 2015

Volume: 31

Affiliations

[1 ] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

[2 ] Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.

[3 ] Animal Husbandry and Veterinary Institute, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China.

[4 ] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: flwnp2013@163.com.

Article

Publisher Item ID: S1567-1348(15)00032-5

DOI: 10.1016/j.meegid.2015.01.019

PubMed ID: 25653129

SO-VID: 9962013c-a8b7-4103-a36d-3ef20278d89f

History

Keywords: Avian influenza virus,China,H5N6,Poultry,Virus reassortment

Data availability:

Keywords: Avian influenza virus, China, H5N6, Poultry, Virus reassortment

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