+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Reduced Growth Hormone Secretion in Turner Syndrome: Is Body Weight a Key Factor?

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The age-related decline in spontaneous growth hormone (GH) secretion has been suggested to cause growth failure in girls with Turner syndrome (TS). We studied 23 girls (mean age ± SD: 11.1 ± 2.7 years) diagnosed to have TS by karyotype analysis. The control group consisted of 18 prepubertal age-matched subjects (10.7 ± 2.5 years) with growth retardation due to familial short stature and/or constitutional growth delay. In addition, 18 children (10.9 ± 3.3 years) diagnosed to have GH deficiency by two different provocative tests were chosen as a further comparison group. Spontaneous 12-hour nocturnal GH secretion was assessed by RIA at 30-min intervals. Plasma insulin-like growth factor 1 (IGF-1) levels were determined by RIA after acid-ethanol extraction. Girls with TS had a percentage of ideal body weight significantly higher than controls (p < 0.0001) and showed spontaneous GH secretion significantly lower than controls (mean ± SD: 3.2 ± 1.6 in TS vs. 5.5 ± 1.3 µg/l in controls; p < 0.0001) but higher than GH-deficient patients (1.3 ± 0.8 µg/l; p < 0.0001). No significant difference was found in IGF-1 levels between TS patients and controls, whereas GH-deficient children showed IGF-1 levels significantly lower than those of TS patients (p < 0.0005). As expected, GH concentrations correlated with bone age in controls (r = 0.51, p < 0.05), whereas no relationship was seen in TS. Interestingly, in TS, GH levels were negatively related to the percentage of ideal body weight (r = -0.43, p < 0.05). The finding of GH levels intermediate between control and GH-deficient patients together with normal IGF-1 concentrations, questions the existence of a ‘classical’ GH insufficiency in TS girls. This study confirms that weight excess is a common feature of TS girls at pubertal age and suggests that the reduced GH secretion might be due, at least in part, to obesity.

          Related collections

          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 41
          : 1
          : 27-32
          Departments of Paediatrics, a‘Tor Vergata’ University and b>‘La Sapienza’ University, Rome, Italy
          183873 Horm Res 1994;41:27–32
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Original Paper


          Comment on this article