24
views
0
recommends
+1 Recommend
2 collections
    0
    shares

          The flagship journal of the Society for Endocrinology. Learn more

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A commonly overlooked motor neuron disease mimicker

      research-article

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Summary

          Motor neuron disease (MND) is a progressive devastating neurodegenerative disease, which universally progresses towards death. Hence, every attempt should be made to find out if there are any treatable conditions, which can mimic MND. Herein, we describe a case of hypercalcaemia due to primary hyperparathyroidism confused as MND and subsequently cured with parathyroid surgery.

          Learning points

          • Any patient with neurological disorder should have a screening of all the common electrolytes including calcium as electrolyte imbalance can present with paralysis (e.g. hypokalaemia) to amyotrophic lateral sclerosis (e.g. hypercalcaemia).

          • No patient should be stamped as having MND without having a proper work-up of all its differentials as there might be a treatable condition masquerading as MND.

          Related collections

          Most cited references12

          • Record: found
          • Abstract: found
          • Article: not found

          Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis.

          We have tested the sensitivity of a recently published approach to combining clinical and EMG data in the 'research diagnosis' of ALS, in 55 consecutive patients clinically diagnosed with ALS. The application of this 'Awaji algorithm' to the revised El Escorial diagnostic criteria for diagnosis of ALS achieved a diagnostic sensitivity of 95% for definite ALS compared with 18% using the clinical El Escorial criteria and 53% when the EMG criteria as defined in the El Escorial criteria, were applied to the same dataset. This increased sensitivity was particularly relevant for bulbar onset patients (sensitivity improved from 38% to 87%) and for patients with El Escorial clinically possible ALS (from 50% to 86%). We suggest that, in future, investigators and triallists should use the Awaji algorithm superimposed onto the El Escorial criteria, in selecting patients for research studies.
            • Record: found
            • Abstract: not found
            • Article: not found

            Neuromuscular disease in primary hyperparathyroidism.

              • Record: found
              • Abstract: found
              • Article: not found

              Primary hyperparathyroidism simulating motor neuron disease: case report.

              We report a case of a 26-year-old man who presented a lower motor neuron syndrome due to hyperparathyroidism. Electromyography showed neurogenic features with normal nerve conduction studies. Hypercalcemia led to the discovery of a primary hyperparathyroidism with gland hyperplasia. Following parathyroid surgery there was recovery of the neurological symptoms.

                Author and article information

                Journal
                Endocrinol Diabetes Metab Case Rep
                Endocrinol Diabetes Metab Case Rep
                edm
                EDM Case Reports
                Endocrinology, Diabetes & Metabolism Case Reports
                Bioscientifica Ltd (Bristol )
                2052-0573
                1 November 2014
                2014
                : 2014
                : 140085
                Affiliations
                [1]Sanjiban Hospital , Kolkata, India
                [1 ]Department of Medicine, Sanjiban Hospital , Kolkata, India
                [2 ]Department of Medicine, Malda Medical College , Malda, West Bengal, 732101, India
                [3 ]Department of Neurology, NRS Medical College , Kolkata, India
                [4 ]Department of Medicine, College of Medicine and Sagore Dutta Hospital , Kolkata, India
                [5 ]Department of Medicine, NRS Medical College , Kolkata, India
                Author notes
                Correspondence should be addressed to K Ghosh Email: drkaushikghosh@ 123456gmail.com
                Article
                EDM140085
                10.1530/EDM-14-0085
                4261199
                27168935
                997e1b08-3580-48bc-a69a-b0259d7a7883
                © 2014 The authors

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

                History
                : 3 October 2014
                : 28 October 2014
                Categories
                Error in Diagnosis/Pitfalls and Caveats

                Comments

                Comment on this article

                Related Documents Log