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      Clinical Interventions in Aging (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on prevention and treatment of diseases in people over 65 years of age. Sign up for email alerts here.

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      Lens-induced glaucoma in the elderly

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          Abstract

          Lens-induced glaucoma comprises a number of different glaucomatous processes occurring in the elderly that share in common the role of the crystalline lens in the mechanism of increase in intraocular pressure. We will review the anatomic predisposing factors, their physiology, signs and symptoms, and therapeutic approach. We will consider two studies and discuss the visual results and risk factors associated with these pathologic conditions.

          Most cited references48

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          Aetiology of the anatomical basis for primary angle-closure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma.

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            Volume and depth of the anterior chamber in the normal aging human eye.

            The dimensions of the anterior chamber were studied in 624 eyes of normal subjects ranging in age from 10 to 70 years. It was found that the depth and volume of the anterior chamber diminish with age and are related to the degree of ametropia. Male subjects had larger anterior chamber dimensions than female subjects. Frequency distributions suggested that these dimensions were distributed normally in the test population. Age- and sex-corrected percentile nomograms are illustrated, which can be used to predict the likelihood of finding a particular anterior chamber dimension in a normal eye.
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              Diagnosis and management of lens-induced glaucoma.

              Lens-induced glaucoma may occur as either secondary angle-closure or open-angle glaucoma. Dislocation or swelling of the lens can cause pupillary block and subsequent angle-closure glaucoma. Leakage of soluble lens proteins from a relatively intact cataractous lens can result in a severe secondary open-angle glaucoma (phacolytic glaucoma). Heavy molecular weight protein, believed to be of lens origin, has now been identified in 12 of 12 anterior chamber specimens from such patients. This liberated lens protein can directly obstruct the trabecular outflow pathways. After extracapsular cataract surgery or after lens trauma, liberated fragments of lens material may mechanically impair the drainage of aqueous humor through the outflow channels (lens particle glaucoma). The diagnosis and management of these different lens-induced glaucomas are reviewed. With proper recognition, these glaucomas are promptly cured by the surgical removal of the lens (material).
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                Author and article information

                Journal
                Clin Interv Aging
                Clinical Interventions in Aging
                Dove Medical Press
                1176-9092
                1178-1998
                2009
                2009
                3 August 2009
                : 4
                : 331-336
                Affiliations
                Department of Ophthalmology, University of Athens, Athens, Greece
                Author notes
                Correspondence: Dimitris Papaconstantinou, Consultant Ophthalmic Surgeon, Mesogeion Ave, Athens, Greece, email dpapaconstantinou@ 123456hotmail.com
                Article
                cia-4-331
                2722872
                19696897
                99847ca0-76c3-4ed1-8f3a-a0e898c53641
                © 2009 Papaconstantinou et al, publisher and licensee Dove Medical Press Ltd.

                This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

                History
                Categories
                Review

                Health & Social care
                glaucoma,intraocular pressure
                Health & Social care
                glaucoma, intraocular pressure

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