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      MiR-430 Can Affect the Mesoderm Formation and Metamorphosis of Paralichthys olivaceus by Targeting lefty Gene

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          Abstract

          MiR-430 is a non-coding small RNA that participates in early embryonic development by acting on the Nodal signaling pathway. Its functions in Paralichthys olivaceus ( P. olivaceus), however, remain unclear. In this study, through biological information technology, we hypothesized lefty was the target gene of miR-430. Lefty is a divergent member of the transforming growth factor-β (TGF-β) superfamily, and is involved in regulating left-right patterning as an antagonist of the Nodal signaling pathway. To study the relationship between miR-430 and lefty gene, miR-430 and fluorescent expression vector were transfected into embryo cells. Our results showed that miR-430 has important effects on early embryonic development. It can inhibit the expressions of lefty and other genes related to Nodal signaling pathway. Additionally, the expression of miR-430 was involved in the metamorphosis of P. olivaceus. This study clarifies the function of miR-430 in P. olivaceus, which will be helpful for further research on the interactions between miR-430 and the Nodal signaling pathway.

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          Author and article information

          Journal
          JOUC
          Journal of Ocean University of China
          Science Press and Springer (China )
          1672-5182
          24 January 2020
          01 April 2020
          : 19
          : 2
          : 409-416
          Affiliations
          1Key Laboratory of Marine Genetics and Breeding, Ministry of Education, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
          Author notes
          *Corresponding author: WANG Zhigang, E-mail: zgwang@ 123456ouc.edu.cn
          Article
          s11802-020-4131-z
          10.1007/s11802-020-4131-z
          Copyright © Ocean University of China, Science Press and Springer-Verlag GmbH Germany 2020.

          The copyright to this article, including any graphic elements therein (e.g. illustrations, charts, moving images), is hereby assigned for good and valuable consideration to the editorial office of Journal of Ocean University of China, Science Press and Springer effective if and when the article is accepted for publication and to the extent assignable if assignability is restricted for by applicable law or regulations (e.g. for U.S. government or crown employees).

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          Self URI (journal-page): https://www.springer.com/journal/11802

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