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      Influence of Urinary Calcium Concentration on Erythrocyte Morphology

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          Abstract

          The effect of the urinary calcium concentration (CaU) on erythrocyte morphology was studied by incubating erythrocytes in urine with prefixed CaUs of 5, 10, 20 and 40 mmol/l by addition of CaCl<sub>2</sub>. The same experiment was carried out on erythrocytes preincubated with levo-verapamil (1-V) at 10,100 and 200 μmol/l. Phase contrast microscopy observations were performed at 0, 30, 60, 120, and 240 min by 2 experienced investigators. At 0 min the erythrocytes showed a clear extraglomerular pattern. At 60 min marked morphological and volumetric alterations were evident when the CaU was > 10 mmol/l. On the contrary, no change was found when red cells were treated with > 100 μmol/l 1-V, independent of the CaU. Dysmorphic erythrocyturia has been related to transglomerular passage even if it was sporadically observed in hypercalciuric or lithiasic patients. This work suggests a role for a high CaU in causing the formation of microcytic and warped erythrocytes. In our opinion, in hypercalciuric urine the appearance of dysmorphic or mixed hematuria does not necessarily indicate transglomerular passage.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1996
          1996
          24 December 2008
          : 74
          : 4
          : 661-667
          Affiliations
          Departments of aNephrology and bPediatrics, Modena University, Modena, Italy
          Article
          189471 Nephron 1996;74:661–667
          10.1159/000189471
          8956298
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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