52
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Explaining Causal Findings Without Bias: Detecting and Assessing Direct Effects

      Read this article at

      ScienceOpenPublisher
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Researchers seeking to establish causal relationships frequently control for variables on the purported causal pathway, checking whether the original treatment effect then disappears. Unfortunately, this common approach may lead to biased estimates. In this article, we show that the bias can be avoided by focusing on a quantity of interest called the controlled direct effect. Under certain conditions, the controlled direct effect enables researchers to rule out competing explanations—an important objective for political scientists. To estimate the controlled direct effect without bias, we describe an easy-to-implement estimation strategy from the biostatistics literature. We extend this approach by deriving a consistent variance estimator and demonstrating how to conduct a sensitivity analysis. Two examples—one on ethnic fractionalization’s effect on civil war and one on the impact of historical plough use on contemporary female political participation—illustrate the framework and methodology.

          Related collections

          Most cited references21

          • Record: found
          • Abstract: not found
          • Article: not found

          Nonparametric Estimation of Average Treatment Effects Under Exogeneity: A Review

            • Record: found
            • Abstract: found
            • Article: not found

            Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.

            Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there exist time-dependent confounders that are themselves affected by previous treatment or exposure. Marginal structural models are a new class of causal models the parameters of which are estimated through inverse-probability-of-treatment weighting; these models allow for appropriate adjustment for confounding. We describe the marginal structural Cox proportional hazards model and use it to estimate the causal effect of zidovudine on the survival of human immunodeficiency virus-positive men participating in the Multicenter AIDS Cohort Study. In this study, CD4 lymphocyte count is both a time-dependent confounder of the causal effect of zidovudine on survival and is affected by past zidovudine treatment. The crude mortality rate ratio (95% confidence interval) for zidovudine was 3.6 (3.0-4.3), which reflects the presence of confounding. After controlling for baseline CD4 count and other baseline covariates using standard methods, the mortality rate ratio decreased to 2.3 (1.9-2.8). Using a marginal structural Cox model to control further for time-dependent confounding due to CD4 count and other time-dependent covariates, the mortality rate ratio was 0.7 (95% conservative confidence interval = 0.6-1.0). We compare marginal structural models with previously proposed causal methods.
              • Record: found
              • Abstract: not found
              • Article: not found

              The Slave Trade and the Origins of Mistrust in Africa

                Author and article information

                Journal
                applab
                American Political Science Review
                Am Polit Sci Rev
                Cambridge University Press (CUP)
                0003-0554
                1537-5943
                August 2016
                September 2016
                : 110
                : 03
                : 512-529
                Article
                10.1017/S0003055416000216
                99a30336-5d1a-4dbb-a456-7b42dfb312b8
                © 2016
                History

                Comments

                Comment on this article

                Related Documents Log