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      Streptomyces pneumonia in a patient with human immunodeficiency virus infection: case report and review of the literature on invasive streptomyces infections.

      Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
      AIDS-Related Opportunistic Infections, drug therapy, microbiology, Actinomycetales Infections, diagnosis, Adult, Anti-Bacterial Agents, therapeutic use, Clarithromycin, Humans, Male, Pneumonia, Bacterial, Streptomyces, isolation & purification

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          Abstract

          Streptomyces species are most widely known for their production of antimicrobial substances and, apart from mycetoma, have rarely been reported as a cause of infection. We describe a patient with early human immunodeficiency virus infection who presented with fever, cough, and nodular pulmonary infiltrates. Open lung biopsy revealed necrotic tissue and a sulfur granule; aerobic bacterial cultures yielded Streptomyces species. The patient was treated successfully with clarithromycin for 6 months. We review the clinical presentation and treatment of invasive streptomyces infections.

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