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      Oxytocin in Microdissected Hypothalamic Nuclei

      ,

      Neuroendocrinology

      S. Karger AG

      Hypothalamus, Puberty, Oxytocin

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          Abstract

          We measured the concentration of oxytocin and vasopressin in microdissected areas of the hypothalamus and posterior pituitary in weanling and adult female rats. Oxytocin concentration was significantly less in adult rats as compared to weanling rats in the supraoptic nucleus, median eminence, and retrochiasmatic area with no significant differences in vasopressin content. This may indicate differences in hypothalamic-neurohypophyseal pathways in adult and weanling rats. There was a significantly greater concentration of oxytocin in the adult rat in the paraventricular nucleus, suprachiasmatic nucleus, anterior hypothalamic nucleus, and posterior pituitary, again with no significant difference in vasopressin concentration. Our results are consistent with a role for sexual maturation in increasing synthesis of oxytocin in specific hypothalamic nuclei resulting in increased storage of oxytocin in the posterior pituitary.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1980
          1980
          26 March 2008
          : 31
          : 2
          : 158-160
          Affiliations
          Ohio State University Hospital, Columbus, Ohio
          Article
          123067 Neuroendocrinology 1980;31:158–160
          10.1159/000123067
          7393410
          © 1980 S. Karger AG, Basel

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          Pages: 3
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          Original Paper

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