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Abstract
Endotoxin, a lipopolysaccharide component of outer cell wall membrane of the Gram-negative
bacteria is a factor responsible for a number of biological effects including immunostimulatory
activities in different animal species including fish. In this study, L. rohita yearlings
of weight ranging from 80 to 100g were injected intraperitoneally with 0.5, 1, 2,
5, 10 and 20 EU/fish dose of endotoxin to find out its effect on the immunity. The
L. rohita yearlings were found to resist the endotoxin dose up to 20 EU/fish and at
the lower doses, i.e., at 1 and 2 EU/fish; it acted as an immune potentiator. Different
serum and immune parameters like protein, globulin, lysozyme, respiratory burst activity,
myeloperoxidase activity, natural agglutination titre were found to be significantly
high (p<0.01) at a dose of 1 EU/fish. While at 10 and 20 EU/fish, most of these parameters
were lower thereby indicating the immuno-suppressive nature of the endotoxin at these
higher doses.