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      Menstrual cyclicity post OC withdrawal in PCOS: Use of non-hormonal options.

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          Abstract

          There is no data on menstrual cyclicity post oral contraceptive (OC) withdrawal with nonhormonal options in PCOS patients. OC could affect obesity, insulin and gonadotropins factors integral to pathogenesis of PCOS, thereby adversely affecting the HPG axis. Menstrual cycles of PCOS patients were retrospectively studied post OCP. Patients developing regular versus irregular cycles post OC were compared. Forty-eight PCOS patients were followed for an average of 1.9 years post OC. Thirty-six (75%) achieved regular cycles over a period of one year with other nonhormonal options like spironolactone and metformin. Seven patients required no treatment. Patients who continued to have irregular cycles had a longer pre OC cycle length (p < 0.01) and a greater duration of menstrual irregularity (p < 0.02), though age, BMI and hormones were similar in the two groups. In conclusion, spironolactone and metformin are effective nonhormonal options for regular periods post OC. Around 15% PCOS may not require any treatment post OC.

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          Author and article information

          Journal
          J Obstet Gynaecol
          Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
          Informa UK Limited
          1364-6893
          0144-3615
          Aug 2016
          : 36
          : 6
          Affiliations
          [1 ] a Department of Endocrinology and.
          [2 ] b Department of Biochemistry , PGIMER, Dr RML Hospital , Delhi, India.
          Article
          10.3109/01443615.2016.1159667
          26982394
          99cde632-7656-48c5-bde8-d5a95fc20234
          History

          Resumption,post OCP,menstrual cycles,periods,oral contraceptive withdrawal,OC withdrawal

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