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      Plasma Growth Hormone Levels in Rats with Increased Naso-Anal Lengths Due to Hypothalamic Surgery

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          Abstract

          A modification of the Halász-Pupp neurosurgical knife was used in female rats to completely or partially isolate the medial basal hypothalamus from the adjacent central nervous. Changes in body weight and length, plasma GH levels, and GH metabolism were measured. Whereas complete or anterior knife cuts resulted in increased body length and weight, posterior cuts had no effect. At 7 months following surgery, non-stress plasma GH levels were not elevated in any group, including those exhibiting enhanced linear growth. Ether stress decreased mean plasma GH levels significantly in all groups except that with complete cuts; nevertheless, most animals with complete cuts responded to stress with decreases in plasma GH. GH turnover rates in heavy animals of normal length did not differ from those in intact controls. In contrast, animals that were both heavier and longer than controls exhibited a decreased turnover rate and increased t<sub>1/2</sub> of <sup>125</sup>I-labeled GH. Volumes of distribution of GH were comparable in intact and operated rats of normal length but markedly increased in those of exceptional length. Although no increase in non-stress plasma GH levels was observed at 7 months following surgery in animals

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 10
          : 1
          : 31-45
          Affiliations
          Departments of Anatomy and Physiology, Baylor College of Medicine, Houston, Texas
          Article
          122075 Neuroendocrinology 1972;10:31–45
          10.1159/000122075
          5037212
          99da3e5e-f12d-4a04-9045-20f71ed207ec
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 19 November 1971
          : 15 February 1972
          Page count
          Pages: 15
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          GH metabolism,Naso-anal length system,Hypothalamic cuts,Plasma GH

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