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Safety and toxicokinetics of intravenous liposomal amphotericin B (AmBisome) in beagle dogs.
I Bekersky 1 , G W Boswell , R Hiles , R M Fielding , D Buell , T J Walsh
Nov 1999
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Abstract
Amphotericin B (AmB) in small, unilamellar liposomes (AmBisome) has an improved therapeutic index, and altered pharmacokinetics. The repeat-dose safety and toxicokinetic profiles of AmBisome were studied at clinically relevant doses.