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      Calorie restriction, SIRT1 and metabolism: understanding longevity.

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          Abstract

          Calorie restriction (CR) is the only experimental manipulation that is known to extend the lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non-human primates. In addition, CR has been shown to reduce the incidence of age-related disorders (for example, diabetes, cancer and cardiovascular disorders) in mammals. The mechanisms through which this occurs have been unclear. CR induces metabolic changes, improves insulin sensitivity and alters neuroendocrine function in animals. In this review, we summarize recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0072
          1471-0072
          Apr 2005
          : 6
          : 4
          Affiliations
          [1 ] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
          Article
          nrm1616
          10.1038/nrm1616
          15768047
          99f053c4-4baa-4b81-ab33-56685fe22e33
          History

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