Wenda Guan 1 , Zifeng Yang 1 , Nicholas C Wu 5 , Horace H Y Lee 2 , Yimin Li 1 , Wenxin Jiang 3 , Lihan Shen 4 , Douglas C Wu 7 , Rongchang Chen 1 , Nanshan Zhong 1 , Ian A Wilson 5 , 6 , Malik Peiris 1 , 2 , Chris K P Mok 1 , 2
28 May 2018
This study correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection with clinical data of patients. Biologically significant transcriptomic profiles associated with blood oxygenation and viral load in the lower respiratory tract were defined.
Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.