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      Applications of Capillary Electrophoresis in Nephrology

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          Capillary electrophoresis has recently emerged as a powerful technique for separating components in biological samples. A family of separation methods capable of handling a diverse range of samples has been developed, the sample volumes required are very small and a wide range of specialised detectors can be employed. This review examines some methods with particular application to the analysis of urine and tubular fluid samples and references relevant applications.

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          Most cited references 12

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          Determination of Catecholamines and Related Compounds by Capillary Electrophoresis with Postcolumn Terbium Complexation and Sensitized Luminescence Detection

           Ruohua Zhu,  Wim Kok (1997)
          A method has been developed for the determination of catecholamines and related compounds (DA, E, NE, DOPA, DOPAC, DOPAG) in urine samples. The compounds of interest were separated by capillary electrophoresis with a borate buffer as background electrolyte. Detection was based on the sensitized luminescence of terbium ions. Using a homemade postcolumn reactor, a basic solution containing a stoichiometric mixture of terbium(III) chloride and EDTA was added postcolumn to the separation buffer. The ternary catechol-EDTA-terbium complexes formed in the reaction mixture showed a strong luminescence with excitation and emission maxima at 300 and 545 nm, respectively. By optimization of the experimental conditions, zone broadening could be restrained and plate numbers up to 130,000 appeared to be possible. Detection limits found were in the order of 10(-7) mol L-1. The catecholic compounds could be determined in urine samples after a standard cleanup and preconcentration procedure.
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            Capillary electrophoresis of urinary porphyrins with absorbance and fluorescence detection

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              Capillary electrophoresis as a clinical tool


                Author and article information

                Nephron Exp Nephrol
                Cardiorenal Medicine
                S. Karger AG
                October 1998
                11 September 1998
                : 6
                : 5
                : 415-420
                a Centre for Analytical Science, Birkbeck College, London, and b Department of Pharmacy, Kings College, London, UK
                20550 Exp Nephrol 1998;6:415–420
                © 1998 S. Karger AG, Basel

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                Page count
                Figures: 3, Tables: 1, References: 62, Pages: 6
                Self URI (application/pdf):
                Functional Insights from Analysis of Biological Fluids

                Cardiovascular Medicine, Nephrology

                Capillary electrophoresis, Separation methods


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