Partial Purification of Renal Lysosomal Substances Producing Angionecrosis and Increased Vascular Permeability

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Abstract

The lysosomal contents of hog kidney cortex, which induce angionecrosis and/or an increase of vascular permeability, were obtained by differential centrifugation and osmotic shock treatment, and were purified by various chromatographic techniques and electrophoresis. The material producing an increase in vascular permeability of the rabbit skin was purified 600-fold over the homogenate; however, it showed practically no angionecrotic activity. Another substance producing angionecrosis without pressor activity was partially purified.

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Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISBN: 978-3-8055-2857-3

ISBN: 978-3-318-02028-1

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 18 September 2008

Volume: 15

Issue: 1-3

Pages: 119-127

Affiliations

Research Institute of Angiocardiology and Cardiovascular Clinic and Department ofPathology, Medical School and Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka

Article

Publisher ID: 158158 Other ID: Blood Vessels 1978;15:119–127

DOI: 10.1159/000158158

SO-VID: 9a02d138-9132-4785-acc8-4844ba313d07

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Partial Purification of Renal Lysosomal Substances Producing Angionecrosis and Increased Vascular Permeability

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Karger: Cardiovascular System

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