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      A genome-wide association study identifies genomic loci associated with backfat thickness, carcass weight, and body weight in two commercial pig populations.

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          Abstract

          Growth and fatness traits are economically important in the pig industry. To dissect the genetic architecture of these traits in commercial pigs, we conducted a genome-wide association study (GWAS) for carcass weight, backfat thickness, and body weight in two commercial populations: Duroc × (Landrace × Yorkshire) (DLY) and Duroc populations. To enhance the detection power, three GWAS approaches including single-trait GWAS, multi-trait GWAS and meta-analysis were used in this study. A total of 13 suggestive loci were identified on nine chromosomes. The most significant locus was detected at 272.05 Mb on SSC1, and it was associated with backfat thickness at the first rib in the DLY population. Three genes at the identified loci (TBC1D1, BAAT and PHLPP1) were highlighted as functionally plausible candidate genes for pig growth and fatness traits. Genome-wide significant locus was not evidenced in this study, indicating that large populations are required to identify QTL with minor effects on growth and fatness traits in commercial pig populations, in which intensively artificial selections have been imposed on these traits and small genetical variances usually retain in these traits.

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          Author and article information

          Journal
          J. Appl. Genet.
          Journal of applied genetics
          Springer Nature America, Inc
          2190-3883
          1234-1983
          Nov 2017
          : 58
          : 4
          Affiliations
          [1 ] State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
          [2 ] College of Animal Science and National Engineering Research Center for Swine Breeding Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
          [3 ] National Engineering Research Center for Swine Breeding, Guangdong Wens Foodstuff Co. Ltd., Xinxing, 527439, China.
          [4 ] State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China. renjunjxau@hotmail.com.
          Article
          10.1007/s13353-017-0405-6
          10.1007/s13353-017-0405-6
          28890999
          9a192823-7c16-4f79-ab9b-a92604ee87bf

          Meta-analysis,Pig,Backfat thickness,Body weight,Carcass weight,Genome-wide association study

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