1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus.

      Development (Cambridge, England)
      Animals, Brain, embryology, Mothers, Organ Size, Protein Stability, Receptors, Notch, physiology, Xenopus Proteins, metabolism, Xenopus laevis, beta Catenin

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.

          Related collections

          Author and article information

          Journal
          21610033
          10.1242/dev.061143

          Chemistry
          Animals,Brain,embryology,Mothers,Organ Size,Protein Stability,Receptors, Notch,physiology,Xenopus Proteins,metabolism,Xenopus laevis,beta Catenin

          Comments

          Comment on this article