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      Evaluation of the Renin-Aldosterone System during Hypo- and Hyperglycemia in Children and Adolescents

      , , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Renin, Aldosterone, Hypoglycemia, Hyperglycemia

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          Abstract

          The effect of hypo- and hyperglycemia on the renin-aldosterone system was studied in 10 endocrinologically normal children. Insulin-induced hypoglycemia caused an elevation of plasma renin activity (PRA) up to 371 ± 23% (mean ± SEM) over the basal level (p < 0.001) and of the plasma aldosterone level up to 243 ± 7% (mean ± SEM) over the basal values (p < 0.001). Hyperglycemia caused an elevation of PRA up to 135 ± 40% (mean ± SEM) over the basal values (p > 0.05) and a reduction in the plasma aldosterone level to 53 ± 12% (mean ± SEM, p < 0.01). It is suggested that the widely used diagnostic procedures, the insulin tolerance and oral glucose tolerance tests, be also applied for the investigation of the renin-aldosterone system.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1980
          1980
          25 November 2008
          : 12
          : 1
          : 16-21
          Affiliations
          Institute of Pediatric and Adolescent Endocrinology and Endocrine Laboratory, Beilinson Medical Center, Petah Tikva, and Sackler School of Medicine, Tel Aviv University, Tel Aviv
          Article
          179101 Horm Res 1980;12:16–21
          10.1159/000179101
          6988319
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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