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      Evaluation of the Renin-Aldosterone System during Hypo- and Hyperglycemia in Children and Adolescents

      , , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Renin, Aldosterone, Hypoglycemia, Hyperglycemia

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          The effect of hypo- and hyperglycemia on the renin-aldosterone system was studied in 10 endocrinologically normal children. Insulin-induced hypoglycemia caused an elevation of plasma renin activity (PRA) up to 371 ± 23% (mean ± SEM) over the basal level (p < 0.001) and of the plasma aldosterone level up to 243 ± 7% (mean ± SEM) over the basal values (p < 0.001). Hyperglycemia caused an elevation of PRA up to 135 ± 40% (mean ± SEM) over the basal values (p > 0.05) and a reduction in the plasma aldosterone level to 53 ± 12% (mean ± SEM, p < 0.01). It is suggested that the widely used diagnostic procedures, the insulin tolerance and oral glucose tolerance tests, be also applied for the investigation of the renin-aldosterone system.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 12
          : 1
          : 16-21
          Institute of Pediatric and Adolescent Endocrinology and Endocrine Laboratory, Beilinson Medical Center, Petah Tikva, and Sackler School of Medicine, Tel Aviv University, Tel Aviv
          179101 Horm Res 1980;12:16–21
          © 1980 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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