Environmental Survival of SARS-CoV-2 – A solid waste perspective

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Abstract

The advent of COVID-19 has kept the whole world on their toes. Countries are maximizing their efforts to combat the virus and to minimize the infection. Since infectious microorganisms may be transmitted by variety of routes, respiratory and facial protection is required for those that are usually transmitted via droplets/aerosols. Therefore this pandemic has caused a sudden increase in the demand for personal protective equipment (PPE) such as gloves, masks, and many other important items since, the evidence of individual-to-individual transmission (through respiratory droplets/coughing) and secondary infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). But the disposal of these personal protective measures remains a huge question mark towards the environmental impact. Huge waste generation demands proper segregation according to waste types, collection, and recycling to minimize the risk of infection spread through aerosols and attempts to implement measures to monitor infections. Hence, this review focuses on the impact of environment due to improper disposal of these personal protective measures and to investigate the safe disposal methods for these protective measures by using the safe, secure and innovative biological methods such as the use of Artificial Intelligence (AI) and Ultraviolet (UV) lights for killing such deadly viruses.

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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

Neeltje van Doremalen, Trenton Bushmaker, Dylan H Morris … (2021)

To the Editor: A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic. 1 We analyzed the aerosol and surface stability of SARS-CoV-2 and compared it with SARS-CoV-1, the most closely related human coronavirus. 2 We evaluated the stability of SARS-CoV-2 and SARS-CoV-1 in aerosols and on various surfaces and estimated their decay rates using a Bayesian regression model (see the Methods section in the Supplementary Appendix, available with the full text of this letter at NEJM.org). SARS-CoV-2 nCoV-WA1-2020 (MN985325.1) and SARS-CoV-1 Tor2 (AY274119.3) were the strains used. Aerosols (<5 μm) containing SARS-CoV-2 (105.25 50% tissue-culture infectious dose [TCID50] per milliliter) or SARS-CoV-1 (106.75-7.00 TCID50 per milliliter) were generated with the use of a three-jet Collison nebulizer and fed into a Goldberg drum to create an aerosolized environment. The inoculum resulted in cycle-threshold values between 20 and 22, similar to those observed in samples obtained from the upper and lower respiratory tract in humans. Our data consisted of 10 experimental conditions involving two viruses (SARS-CoV-2 and SARS-CoV-1) in five environmental conditions (aerosols, plastic, stainless steel, copper, and cardboard). All experimental measurements are reported as means across three replicates. SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A). SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected up to 72 hours after application to these surfaces (Figure 1A), although the virus titer was greatly reduced (from 103.7 to 100.6 TCID50 per milliliter of medium after 72 hours on plastic and from 103.7 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). The stability kinetics of SARS-CoV-1 were similar (from 103.4 to 100.7 TCID50 per milliliter after 72 hours on plastic and from 103.6 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). On copper, no viable SARS-CoV-2 was measured after 4 hours and no viable SARS-CoV-1 was measured after 8 hours. On cardboard, no viable SARS-CoV-2 was measured after 24 hours and no viable SARS-CoV-1 was measured after 8 hours (Figure 1A). Both viruses had an exponential decay in virus titer across all experimental conditions, as indicated by a linear decrease in the log10TCID50 per liter of air or milliliter of medium over time (Figure 1B). The half-lives of SARS-CoV-2 and SARS-CoV-1 were similar in aerosols, with median estimates of approximately 1.1 to 1.2 hours and 95% credible intervals of 0.64 to 2.64 for SARS-CoV-2 and 0.78 to 2.43 for SARS-CoV-1 (Figure 1C, and Table S1 in the Supplementary Appendix). The half-lives of the two viruses were also similar on copper. On cardboard, the half-life of SARS-CoV-2 was longer than that of SARS-CoV-1. The longest viability of both viruses was on stainless steel and plastic; the estimated median half-life of SARS-CoV-2 was approximately 5.6 hours on stainless steel and 6.8 hours on plastic (Figure 1C). Estimated differences in the half-lives of the two viruses were small except for those on cardboard (Figure 1C). Individual replicate data were noticeably “noisier” (i.e., there was more variation in the experiment, resulting in a larger standard error) for cardboard than for other surfaces (Fig. S1 through S5), so we advise caution in interpreting this result. We found that the stability of SARS-CoV-2 was similar to that of SARS-CoV-1 under the experimental circumstances tested. This indicates that differences in the epidemiologic characteristics of these viruses probably arise from other factors, including high viral loads in the upper respiratory tract and the potential for persons infected with SARS-CoV-2 to shed and transmit the virus while asymptomatic. 3,4 Our results indicate that aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus can remain viable and infectious in aerosols for hours and on surfaces up to days (depending on the inoculum shed). These findings echo those with SARS-CoV-1, in which these forms of transmission were associated with nosocomial spread and super-spreading events, 5 and they provide information for pandemic mitigation efforts.

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Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents

G Kampf, D Todt, S. Pfaender … (2020)

Summary Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for SARS-CoV-2, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread.

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Minimising the present and future plastic waste, energy and environmental footprints related to COVID-19

Jiří Klemeš, Yee Van Fan, Raymond R. Tan … (2020)

The COVID-19 pandemic has had growing environmental consequences related to plastic use and follow-up waste, but more urgent health issues have far overshadowed the potential impacts. This paper gives a prospective outlook on how the disruption caused by COVID-19 can act as a catalyst for short-term and long-term changes in plastic waste management practices throughout the world. The impact of the pandemic and epidemic following through the life cycles of various plastic products, particularly those needed for personal protection and healthcare, is assessed. The energy and environmental footprints of these product systems have increased rapidly in response to the surge in the number of COVID-19 cases worldwide, while critical hazardous waste management issues are emerging due to the need to ensure destruction of residual pathogens in household and medical waste. The concept of Plastic Waste Footprint (PWF) is proposed to capture the environmental footprint of a plastic product throughout its entire life cycle. Emerging challenges in waste management during and after the pandemic are discussed from the perspective of novel research and environmental policies. The sudden shift in waste composition and quantity highlights the need for a dynamically reponsive waste management system. Six future research directions are suggested to mitigate the potential impacts of the pandemic on waste management systems.

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Author and article information

Journal

Journal ID (nlm-ta): Environ Res

Journal ID (iso-abbrev): Environ Res

Title: Environmental Research

Publisher: Elsevier Inc.

ISSN (Print): 0013-9351

ISSN (Electronic): 1096-0953

Publication date PMC-release: 26 March 2021

Publication date (Electronic): 26 March 2021

Electronic Location Identifier: 111015

Affiliations

[a ]Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600- 006, India

[b ]Computational Toxicology Facility, Centre for Innovation and Translational Research, Environmental Monitoring and Intervention Hub (DSIR-CRTDH), CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, M. G. Marg, Lucknow-226001, Uttar Pradesh, India

[c ]Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632 014, Tamil Nadu, India

[d ]Department of Medical laboratory Technology, School of Medical and Allied Health Science, Sanskriti University, Mathura, Uttar Pradesh-281401

[e ]Department of Biotechnology, Lovely Professional University, Punjab 144411, India

[f ]Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046, India

[g ]Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea

[h ]Department of Seed Science and Technology, Tamil Nadu Agricultural University, Coimbatore – 641003, Tamil Nadu, India

[i ]Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel

[j ]Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore-641046, Tamil Nadu, India

[k ]Department of Neurology, National Hospital Organization Utano National Hospital, 8 Ondoyama-Cho, Narutaki, Ukyo-Ku, Kyoto 616-8255, Japan

[l ]Department of Biotechnology, Mizoram University (A Central University), Aizawl – 796 004, Mizoram, India

Author notes

[∗ ]Corresponding author. Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore – 641 046, Tamil Nadu, India Mobile: +91 9994999924; Office: +91 422 2422514; +91 422 2422222

[∗∗ ]Corresponding author. Department of Stem Cell and Regenerative Biotechnology, Incurable Disease Animal Model & Stem Cell Institute (IDASI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. ; Tel.: +82 2 450-4207; fax: +82 2 444-4207

[1]

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Article

Publisher Item ID: S0013-9351(21)00309-1 Publisher ID: 111015

DOI: 10.1016/j.envres.2021.111015

PMC ID: 7997151

PubMed ID: 33775678

SO-VID: 9a890d33-a9c4-4d66-96c7-b83f9e7b1d82

License:

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

History

Date received : 18 November 2020

Date revision received : 14 February 2021

Date accepted : 9 March 2021

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Environmental Survival of SARS-CoV-2 – A solid waste perspective

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Novel Coronavirus Disease COVID-19

Most cited references 61

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents

Minimising the present and future plastic waste, energy and environmental footprints related to COVID-19

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