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      Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro.

      Cancer Letters
      Angiogenesis Inhibitors, pharmacology, Apoptosis, drug effects, Cell Adhesion, Cell Division, Cell Movement, Cells, Cultured, Cinnamates, Depsides, Endothelium, Vascular, cytology, Humans, Immunohistochemistry, Neovascularization, Pathologic, prevention & control, Radioimmunoassay

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          Abstract

          Rosmarinic acid (RA), a water-soluble polyphenolic compound with anti-oxidative and anti-inflammatory activities, inhibited several important steps of angiogenesis including proliferation, migration, adhesion and tube formation of human umbilical vein endothelial cells (HUVEC) in a concentration-dependent manner. RA also reduced intracellular reactive oxygen species (ROS) level, H2O2-dependent VEGF expression and IL-8 release of endothelial cells. These findings suggested that the anti-angiogenic potential of RA might be related to its anti-oxidative activity, which further resulted in the inhibition of ROS-associated VEGF expression and IL-8 release.

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