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      Interaction between Neuronal Amine Uptake and Prejunctional Alpha-Adrenergic Receptor Activation in Smooth Muscle from Canine Blood Vessels and Spleen

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          Experiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-<sup>3</sup>H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 × 10<sup>–6</sup> M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K<sup>+</sup> (40 mEq/l) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of <sup>3</sup>H-norepinephrine or the displacement of <sup>3</sup>H-norepinephrine by tyramine.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 16
          : 3
          : 113-125
          Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minn.
          158198 Blood Vessels 1979;16:113–125
          © 1979 S. Karger AG, Basel

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          Pages: 13
          Original Paper


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