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      Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients.

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          Abstract

          PAFr is a cell adhesion site for specific bacteria, notably non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae. We previously published that PAFr expression is significantly upregulated in the large airways of smokers, especially in COPD. We have now investigated PAFr expression in the epithelium and Rbm of small airways and in the alveolar compartment in smokers and patients with both COPD and small airway disease.

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          Author and article information

          Journal
          Respirology
          Respirology (Carlton, Vic.)
          1440-1843
          1323-7799
          Apr 2016
          : 21
          : 3
          Affiliations
          [1 ] NHMRC Centre of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
          [2 ] School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
          Article
          10.1111/resp.12709
          26662379
          9ac7a0a9-ef24-4d28-9406-0d0857021c8a
          © 2015 Asian Pacific Society of Respirology.
          History

          airway epithelium,chronic obstructive pulmonary disease,inhaled corticosteroid,platelet-activating factor receptor,‘respiratory’ bacteria adhesion

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