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      Clinical Significance of Circulating Immune Complexes Detection in Chronic Glomerulonephritis

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          Abstract

          Sera from 168 patients with various types of chronic glomerulonephritis (GN) were assayed for immune complexes (IC) by two independent methods, a modification of the PEG precipitation test (PEG) and the inhibition of complement-dependent lymphocyte rosette formation (RI). Both assays had different reactivities, the RI being more sensitive than the PEG test. Higher percentages of positivity of these tests were observed in the GN groups than in normal controls. However, serial measurements demonstrated that IC were present only intermittently in most instances. The presence of IC correlated with disease activity in patients with focal glomerulosclerosis membranous GN and membranoproliferative GN, while in lupus erythematosus it reflected the effects of different treatment regimens although it had no relationship with clinical symptoms. Nevertheless, our results suggest that these tests are of little help to the clinician to appreciate disease activity and monitor therapy in individual GN patients.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2981-5
          978-3-318-02025-0
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 1-3
          : 138-145
          Affiliations
          Service de néphrologie, Inserm U 27, et Laboratoire d’immunochimie, Groupe hospitalier Pitié-Salpêtrière, Paris
          Article
          181435 Nephron 1978;22:138–145
          10.1159/000181435
          370624
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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